Using Transdermal Nifedipine for Wound Healing

First Case Study Abstract:

Author: Michael J Torsiello, MD and Matthew Kopacki, RPh

A 43-year-old woman with a history of juvenile diabetes mellitus presented with a nonhealing wound in her right heel. Because of other complications, wound healing was so extended that it was decided to use transdermal nifedipine to accelerate healing by inducing localized vasodilation without systemic effects.  As a result wound healing was decreased from 4 to 5 months to 6 to 8 weeks. Further no adverse effects were observed during therapy.

Complete study: Transdermal Nifedipine for Wound Healing

Second Case Study Abstract:

Author: Michael J Torsiello, MD and Matthew Kopacki, RPh

An 8-year-old boy with a clubfoot developed problems after a foot straightening procedure 2 years earlier.  When the expander was removed, the area was treated with transdermal nifedipine to accelerate wound healing and prevent the formation of a hypertrophic scar. A nifedipine Pluronic Lecithin gel was prescribed in addition to the daily whirlpool therapy. After three weeks of this regimen, complete healing was observed.

Complete study: Transdermal Nifedipine for Wound Healing

To review additional case studies involving transdermal nifedipine treatment see IJPC.com.

Case Report: Topical Gel for the treatment of refractory Leg Ulcer

Author: Alan Israel. IJPC Vol7 No 3; May/June 2004, p. 176

Case Report: Wound Care of a diabetic Foot Ulcer

Author: Tom Wynn. IJPC Vol8 No 4; Jul/Aug 2004, p. 269